Selective Catalysis for Organic Synthesis

Selective Catalysis for Organic Synthesis

Código: 287
Acronimo: SELCAT
Tipo: Grupo consolidado
Categorías: PE5 Synthetic Chemistry and Materials
QMC Química

Lineas de investigación:

1. Development of catalytic methods for the formation of carbon-boron bonds and their application to the synthesis of bioactive compounds: we search for unconventional ways to activate boron compounds in an efficient, inexpensive, and environmentally friendly way. We are especially interested in the formation of C-B bonds that are not possible using a classical approach. In doing so, we want to create a platform of new boron containing molecules that could provide new areas of chemical space for biological screening and simultaneously be a toolbox for the preparation of valuable synthetic intermediates. 2. Development of catalytic methods for the cleavage of carbon-nitrogen bonds and their application to the synthesis of bioactive compounds: The activation of carbon–nitrogen bonds is an important challenge in Organic Synthesis. The ability to access enantioenriched amines readily suggests that the development of practical procedures that utilize carbon–nitrogen bonds in metal-catalyzed transformations has significant potential in synthetic organic chemistry. The goal of this research line is to develop novel asymmetric metal-catalyzed cross-coupling reactions using ammonium salts as starting materials. In doing so, we want to provide new ways to access valuable synthetic intermediates that could be use in the preparation of biologically active compounds. 3. Graphene-Based Heterogenous Catalysis: Graphene Oxide (GO) features a wide range of functional groups which may act as active sites and therefore allows the possibility to develop new sustainable catalytic systems. The aim of thhis line is to take advantage of the properties of graphene looking for a synergistic interaction with metals or organocatalysts to exploit it in the catalysis of organic reactions.

Proyectos más relevantes:

1. Título del proyecto: Design and Applications of Unconventional Borylation Reactions (ERC-Starting Grant) Entidad financiadora: European Research Council (1.495.200 EUR) Duración desde: 01-02-2014 hasta: 31-01-2019 Investigador responsable: Dr. Mariola Tortosa 2. Título del proyecto: Procesos Cataliticos Sostenibles para la Formacion de Enlaces C-B, C-N Y C-C Entidad financiadora: MINECO (117.000 EUR) Duración desde: 01-01-2017 hasta: 31-12-2019 Investigadores responsables: Dr. Mariola Tortosa and Prof. Belén Cid

Publicaciones más relevantes:

1. Guisan-Ceinos, M.; Martin-Heras V.; Tortosa M*., Regio- and Stereospecific Copper-Catalyzed Reactions of Propargylic Ammonium Salts and Aryl Grignard Reagents, J. Am. Chem. Soc. 2017, 139, 8448-8451. 2. Guisan-Ceinos, M.; Parra, A.; Martin-Heras V.; Tortosa M*., Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach, Angew. Chem. Int. Ed. 2016, 55, 6969-6972. 3. Parra, A.; Amenós, L.; Guisan-Ceinos M.; López, A.; Garcia-Ruano, J. L.; Tortosa, M*., Copper-catalyzed diastereo- and enantioselective desymmetrization of cyclopropenes: synthesis of cyclopropylboronates, J. Am. Chem. Soc. 2014, 136, 15833-15836. 4. Alfaro, R; Parra, A.; Alemán, J.; Garcia Ruano, J. L.; Tortosa, M*., Copper(I)-Catalyzed Formal Carboboration of Alkynes: Synthesis of Tri- and Tetrasubstituted Vinylboronates, J. Am. Chem. Soc. 2012, 134, 15165-15168. 5. Morales, S., Guijarro, F. G.; Garcia-Ruano, J. L.*; Cid, M. B.*, A General Aminocatalytic Method for the Synthesis of Aldimines, J. Am. Chem. 2014, 136, 1082-1089.

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