Laboratorio de remodelado vascular

Laboratorio de remodelado vascular

Código: 325
Tipo: Grupo consolidado
Categorías: LS4 Physiology, Pathophysiology and Endocrinology
BMED Biomedicina

Lineas de investigación:

The general subject of our group has been the study of the biological mechanisms implicated in the atherothrombotic diseases (atherosclerosis and abdominal aortic aneurysm, AAA), focusing in the implication of oxidative stress, inflammation and cell stress proteins, and in the identification of new biomarkers in cardiovascular diseases.

Proyectos más relevantes:

1. Analysis of novel mediators and/or therapeutic targets involved in oxidative stress and immune-inflammatory responses in pathological vascular remodelling. SAF2016-80843-R. Ministerio de ciencia e innovación. 2017-2019. PI: Jose Luis Martin-Ventura 2.Basic and clinical implication of proteins identified by proteomic analysis in atherothrombosis. SAF 2013-42525 Ministerio de ciencia e innovación 2014-2016. PI: Jose Luis Martin-Ventura 3. Role of cell stress proteins in atherothrombosis. Ministerio de ciencia e innovación.

Publicaciones más relevantes:

Burillo E, Lindholt JS, Molina-Sánchez P, Jorge I, Martinez-Pinna R, Blanco-Colio LM, Tarin C, Torres-Fonseca MM, Esteban M, Laustsen J, Ramos-Mozo P, Calvo E, Lopez JA, Vega de Ceniga M, Michel JB, Egido J, Andrés V, Vazquéz J, Meilhac O, Martin-Ventura JL.ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression.Thromb Haemost. 2015 Jun;113(6):1335-46 Madrigal-Matute J, Fernandez-Garcia CE, Blanco-Colio LM, Burillo E, Fortuño A, Martinez-Pinna R, Llamas-Granda P, Beloqui O, Egido J, Zalba G, Martin-Ventura JL. Thioredoxin-1/peroxiredoxin-1 as sensors of oxidative stress mediated by NADPH oxidase activity in atherosclerosis. Free Radic Biol Med. 2015 Sep;86:352-6-1 Tarín C, Fernandez-Garcia CE, Burillo E, Pastor-Vargas C, Llamas-Granda P, Castejón B, Ramos-Mozo P, Torres-Fonseca MM, Berger T, Mak TW, Egido J, Blanco-Colio LM, Martín-Ventura JL.Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice. Cardiovasc Res. 2016 Aug 1;111(3):262-73 Burillo E, Tarin C, Torres-Fonseca MM, Fernandez-García CE, Martinez-Pinna R, Martinez-Lopez D, Llamas-Granda P, Camafeita E, Lopez JA, Vega de Ceniga M, Aviram M, Egido J, Blanco-Colio LM, Martín-Ventura JL.Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression.Clin Sci (Lond). 2016 Jun 1;130(12):1027-38 Fernandez-García CE, Tarin C, Roldan-Montero R, Martinez-Lopez D, Torres-Fonseca M, Lindhot JS, Vega de Ceniga M, Egido J, Lopez-Andres N, Blanco-Colio LM, Martín-Ventura JL.Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development.Clin Sci (Lond). 2017 Nov 6;131(22):2707-2719.

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