Bases Moleculares de la Plasticidad Neuronal
Acronimo: NeuroSyn
Tipo: Grupo consolidado
Email:
Categorías: LS5 Neuroscience and Neural Disorders
LS1 Molecular Biology, Biochemistry, Structural Biology and Molecular Biophysics
LS3 Cellular and Developmental Biology
LS4 Physiology, Pathophysiology and Endocrinology
BMED Biomedicina
BFS Área de Biología Fundamental y de Sistemas
FFA Fisiología y Farmacología
Coordinador:
Miembros:
Enlaces:
Lineas de investigación:
Mecanismos moleculares y celulares subyacentes a la plasticidad sináptica. Desarrollo de biosensores fluorescentes para el seguimiento de la señalización asociada a la función sináptica
Proyectos más relevantes:
“Regulation by microRNAs of glutamatergic synapses in ischemia. Development of non-invasive techniques for the study of neurotransmission mediated by glutamate”, 2014-2016, SAF2014-55686-R. “Function of Neurogranin in Synaptic Plasticity”, reference BFU2010-18297, 2011.”Functional analysis of GMC proteins as agents of neuronal plasticity. “In situ” study by means of FRET microscopy, 2003-2005, BFI2002-01581. “Platform for the Development of Animal Health Control Strategies” (PLATESA), ref. P2013 / ABI-2906, Comunidad de Madrid, 2014-2018. “Development of antibody-based probes for the identification, localization and quantification of molecules involved in neuronal function” EMD Millipore Corporation (Merck Group)& FUAM (2016-)
Publicaciones más relevantes:
Neurogranin, a link between calcium/calmodulin and protein kinase C signaling in synaptic plasticity. FJ Díez‐Guerra. IUBMB life 62 (8), 597-606. Neurogranin binds to phosphatidic acid and associates to cellular membranes. I Domínguez-González, SN Vázquez-Cuesta, A Algaba, FJ Díez-Guerra. Biochemical Journal 404 (1), 31-43. Activity-dependent translocation of neurogranin to neuronal nuclei. A Garrido-García, B Andrés-Pans, L Durán-Trío, FJ Díez-Guerra Biochemical Journal 424 (3), 419-429. The Cdk5‐p35 kinase associates with the Golgi apparatus and regulates membrane traffic. G Paglini, L Peris, J Diez‐Guerra, S Quiroga, A Cáceres. EMBO reports 2 (12), 1139-1144. “Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62”. Angelina Rodriguez, Angeles Durán, Mohammed Selloum, Marie-France Champy, F Javier Diez-Guerra, Juana María Flores, Manuel Serrano, Johan Auwerx, María T. Diaz-Meco, and Jorge Moscat. Cell Metabolism 3, 211-222